Comparative Study of Erythrocyte Sedimentation Rate after Aminoglycoside and Aminocyclitol Treatment in Goats (Capra hircus)

Toncho DINEV, Dian KANAKOV, Georgi BEEV, Nikolina RUSENOVA, Stefan DENEV


1Faculty of Agriculture, Department of Biochemistry, Microbiology and Physics, Trakia University, 6000 Stara Zagora, Bulgaria

2Faculty of Veterinary Medicine, Department of Internal Diseases, Trakia University, 6000 Stara Zagora, Bulgaria

3Faculty of Veterinary Medicine, Department of Veterinary Microbiology, Infectious and Parasitic Diseases, Trakia University, Stara Zagora 6000, Bulgaria


Abstract

The aim of the present study was to follow up the erythrocyte sedimentation rate (ESR) in healthy female goats during and after 5-day parenteral treatment with amikacin (10 mg/kg), tobramycin (5 mg/kg), apramycin (20 mg/kg), gentamicin (4 mg/kg), kanamycin (10 mg/kg) and spectinomycin (20 mg/kg). Gentamicin and tobramycin caused an initial increase followed by a significant decrease of ESR on the 5th day for gentamicin and the 10th day for tobramycin, respectively, followed by recovery after the treatment. Reversely, amikacin and especially spectinomycin produced an increase of ESR without recovery several days post treatment. Kanamycin caused decrease of ESR on the 5th day without recovery in the subsequent days. Only apramycin did not give rise to increasing of ESR. In conclusion the aminoglycosides, especially tobramycin and gentamicin, caused more severe alterations of ESR than the aminocyclitols.

*Sorumlu Yazar / Corresponding Author:

Toncho DINEV

e-mail: dinev_sz@mail.bg

Geliş Tarihi / Received:

21 May 2015

Kabul Tarihi / Accepted:

17 November 2015

Key Words:

Amikacin, tobramycin, apramycin, gentamicin, kanamycin, goats, ESR